The impact of acute lymphoblastic leukemia treatment on central nervous system results in Bogota, Colombia

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dc.creatorH, Maria Teresa Amparo Buendia
dc.creatorLozano, Juan Manuel
dc.creatorSuarez, Gloria Elena
dc.creatorA, Carlos Saavedra
dc.creatorGuevara, Gonzalo
dc.date2008
dc.date2020-05-25T23:56:25Z
dc.date.accessioned2023-11-21T15:55:44Z
dc.date.available2023-11-21T15:55:44Z
dc.descriptionTo improve the outcome of children with acute lymphoblastic leukemia (ALL) treated at the National Cancer Institute, Bogota, Colombia, a protocol based on the BFM-90 (Berlin, Frankfurt, Munster study) and the LSA2L 2 regimens was implemented in the year 1993. The patients were classified as being standard risk (SR) or high risk (HR) according to clinical criteria, to which cytogenetic information and day-8 prednisone response were also added. A 123-patient cohort entered the study, 18 of them being considered SR and 105 HR. There was a 94% 10 years' event-free-survival rate for the SR group and 36% for the HR group. Decreased induction death rate (7% vs. 14%), increased complete remission (CR) rate (81% vs. 75%), and continuous CR (45% vs. 33%) were found in comparison with the previous study. A significant improvement was achieved in relapse rate, 44% to 28% (P=0.029), mainly due to reduced central nervous system relapse rate from 16% to 6% (P=0.037), whereas the number of patients receiving cranial radiation was reduced to 55%. A major problem concerned the increased CR mortality rate, 5% to 14% (P=0.06). Improved supportive care therapy and socioeconomic conditions will hopefully reduce the CR mortality rate in the future. © 2008 by Lippincott Williams and amp; Wilkins.
dc.formatapplication/pdf
dc.identifierhttps://doi.org/10.1097/MPH.0b013e31817e4a7d
dc.identifier10774114
dc.identifier15363678
dc.identifierhttps://repository.urosario.edu.co/handle/10336/22419
dc.identifier.urihttp://repository-salesiana.heoq.net/handle/123456789/268047
dc.languageeng
dc.publisherLippincott Williams and Wilkins
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-66249140940&doi=10.1097%2fMPH.0b013e31817e4a7d&partnerID=40&md5=e598420d36c5852e7b9e3e3437f5b342
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectAntineoplastic agent
dc.subjectAsparaginase
dc.subjectCyclophosphamide
dc.subjectCytarabine
dc.subjectDaunorubicin
dc.subjectDexamethasone
dc.subjectDoxorubicin
dc.subjectFolinate calcium
dc.subjectMercaptopurine
dc.subjectMethotrexate
dc.subjectPrednisone
dc.subjectAcute lymphoblastic leukemia
dc.subjectAdolescent
dc.subjectArticle
dc.subjectCancer chemotherapy
dc.subjectCancer mortality
dc.subjectCancer radiotherapy
dc.subjectCancer regression
dc.subjectCancer relapse
dc.subjectCancer risk
dc.subjectCancer survival
dc.subjectCentral nervous system
dc.subjectChild
dc.subjectColombia
dc.subjectControlled study
dc.subjectCytogenetics
dc.subjectDrug dose reduction
dc.subjectDrug megadose
dc.subjectFemale
dc.subjectHuman
dc.subjectInfant
dc.subjectMajor clinical study
dc.subjectMale
dc.subjectMultiple cycle treatment
dc.subjectPreschool child
dc.subjectPriority journal
dc.subjectSchool child
dc.subjectTreatment outcome
dc.subjectTreatment response
dc.subjectAdolescent
dc.subjectAntineoplastic combined chemotherapy protocols
dc.subjectCentral nervous system neoplasms
dc.subjectChild
dc.subjectCohort studies
dc.subjectColombia
dc.subjectCranial irradiation
dc.subjectCytogenetic analysis
dc.subjectHumans
dc.subjectInfant
dc.subjectPrecursor cell lymphoblastic leukemia-lymphoma
dc.subjectPrednisone
dc.subjectRecurrence
dc.subjectRemission induction
dc.subjectRisk
dc.subjectSurvival rate
dc.subjectCns-leukemia
dc.subjectDeveloping country
dc.subjectIntensive chemotherapy
dc.subjectPediatric all
dc.subjectpreschool
dc.subjectChild
dc.titleThe impact of acute lymphoblastic leukemia treatment on central nervous system results in Bogota, Colombia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
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