Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

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dc.creatorKrause, Ilan
dc.creatorFraser, Abigail
dc.creatorBarzilai, Ori
dc.creatorRam, Maya
dc.creatorAbad, Verónica
dc.creatorArango, Alvaro
dc.creatorGarcía, Jorge
dc.creatorShoenfeld, Yehuda
dc.creatorAnaya, Juan-Manuel
dc.date2009
dc.date2020-05-25T23:56:06Z
dc.date.accessioned2023-11-21T15:59:39Z
dc.date.available2023-11-21T15:59:39Z
dc.descriptionType 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. © 2009 New York Academy of Sciences.
dc.formatapplication/pdf
dc.identifierhttps://doi.org/10.1111/j.1749-6632.2009.04619.x
dc.identifier778923
dc.identifierhttps://repository.urosario.edu.co/handle/10336/22322
dc.identifier.urihttp://repository-salesiana.heoq.net/handle/123456789/269226
dc.languageeng
dc.publisherBlackwell Publishing Inc.
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-69949184384&doi=10.1111%2fj.1749-6632.2009.04619.x&partnerID=40&md5=cb5ca52b4678c39a4d4eeb04e58bf50f
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectAutoantibody
dc.subjectBacterium antibody
dc.subjectCardiolipin antibody
dc.subjectCentromere antibody
dc.subjectCytomegalovirus antibody
dc.subjectDouble stranded dna antibody
dc.subjectEpstein barr virus antibody
dc.subjectGliadin antibody
dc.subjectGlomerulus basement membrane antibody
dc.subjectHelicobacter pylori antibody
dc.subjectHepatitis b virus antibody
dc.subjectImmunoglobulin a
dc.subjectImmunoglobulin g
dc.subjectImmunoglobulin g antibody
dc.subjectJo 1 antibody
dc.subjectLa antibody
dc.subjectMyeloperoxidase antibody
dc.subjectProtein glutamine gamma glutamyltransferase antibody
dc.subjectProteinase 3 antibody
dc.subjectProthrombin antibody
dc.subjectProtozoon antibody
dc.subjectRibonucleoprotein antibody
dc.subjectRo antibody
dc.subjectRubella antibody
dc.subjectScl 70 antibody
dc.subjectSm antibody
dc.subjectToxoplasma antibody
dc.subjectUnclassified drug
dc.subjectVirus antibody
dc.subjectAdolescent
dc.subjectAge distribution
dc.subjectAntibody blood level
dc.subjectCeliac disease
dc.subjectConference paper
dc.subjectControlled study
dc.subjectCytomegalovirus
dc.subjectDiabetic patient
dc.subjectDisease association
dc.subjectEpstein barr virus
dc.subjectFamily
dc.subjectFemale
dc.subjectHelicobacter pylori
dc.subjectHepatitis b virus
dc.subjectHepatitis c virus
dc.subjectHuman
dc.subjectInfection sensitivity
dc.subjectInsulin dependent diabetes mellitus
dc.subjectMajor clinical study
dc.subjectMale
dc.subjectNonhuman
dc.subjectRubella
dc.subjectToxoplasma
dc.subjectTreponema pallidum
dc.subjectCytomegalovirus
dc.subjectHelicobacter pylori
dc.subjectHuman herpesvirus 4
dc.subjectToxoplasma
dc.subjectAutoimmunity
dc.subjectCeliac disease
dc.subjectCytomegalovirus
dc.subjectEpstein-barr virus
dc.subjectHelicobacter pylori
dc.subjectInfection
dc.subjectToxoplasma
dc.titleAnti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members
dc.typeinfo:eu-repo/semantics/conferenceObject
dc.typeinfo:eu-repo/semantics/publishedVersion
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